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Details on Person UniProt:D3ZEY4 Dgkq
| Class:Id | ReferenceGeneProduct:9706447 |
|---|---|
| _chainChangeLog | chain:1-937 for 9706447 added on Thu November 5 2020 |
| _displayName | UniProt:D3ZEY4 Dgkq |
| _timestamp | 2025-02-21 18:35:46 |
| chain | chain:1-937 |
| checksum | 9E0EAEAFD5A99716 |
| comment | FUNCTION Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15337525). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:15337525). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (By similarity). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (PubMed:15337525). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (By similarity).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)CATALYTIC ACTIVITY a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)CATALYTIC ACTIVITY 1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)CATALYTIC ACTIVITY 1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)CATALYTIC ACTIVITY 1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)CATALYTIC ACTIVITY 1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)CATALYTIC ACTIVITY 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)ACTIVITY REGULATION Activated by phosphatidylserine.PATHWAY Lipid metabolism; glycerolipid metabolism.SUBUNIT Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires both LXXLL motifs in DGKQ and is required for full phosphatidic acid-mediated activation of NR5A1.SUBCELLULAR LOCATION Translocates to the plasma membrane in response to steroid hormone receptor stimulation. Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH. Translocates to the nucleus in response to thrombin stimulation (By similarity). Association with the nuclear matrix is regulated by nerve growth factor (PubMed:15337525).TISSUE SPECIFICITY Widely expressed with higher expression in the brain and, to a lesser extent, in the small intestine, duodenum, and liver (PubMed:9099683). In brain, expressed in gray matter (PubMed:9099683). Expression is most intense in the cerebellar cortex and hippocampus, while moderate expression is seen in the olfactory bulb neuronal layers and brain stem nuclei (PubMed:9099683). In the cerebellar cortex, equally expressed in both the Purkinje cell somata and the granule cells (PubMed:9099683).DOMAIN The L-X-X-L-L repeats are both required for binding and phosphatidic acid-mediated activation of the nuclear receptor NR5A1.PTM Phosphorylated by PRKCE and PRKCH in vitro.SIMILARITY Belongs to the eukaryotic diacylglycerol kinase family. |
| created | [InstanceEdit:9706439] Weiser, JD |
| description | recommendedName: fullName evidence="10"Diacylglycerol kinase theta shortName: DAG kinase theta shortName evidence="9"DGKtheta ecNumber evidence="7"2.7.1.107 ecNumber evidence="1"2.7.1.93 |
| geneName | Dgkq |
| identifier | D3ZEY4 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell membrane Cytoplasm Cytoskeleton Kinase Lipid metabolism Membrane Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Synapse Transferase Zinc Zinc-finger |
| modified | [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Dgkq |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DGKQ_RAT |
| sequenceLength | 937 |
| species | [Species:48895] Rattus norvegicus |
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No pathways have been reviewed or authored by UniProt:D3ZEY4 Dgkq (9706447)
