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Details on Person UniProt:Q8IG69 cebp-2
| Class:Id | ReferenceGeneProduct:9706446 |
|---|---|
| _chainChangeLog | chain:1-100 for 9706446 added on Thu November 5 2020 |
| _displayName | UniProt:Q8IG69 cebp-2 |
| _timestamp | 2023-11-03 15:25:41 |
| chain | chain:1-100 |
| checksum | C4A65961F3C71BC6 |
| comment | FUNCTION Transcription factor that binds to the promoter and the enhancer regions of target genes (By similarity). Regulates expression of genes involved in fat metabolism, including ech-1.1 and fat-5 (PubMed:26505800). Has a protective role in response to infection by the Gram-negative bacterium P.aeruginosa (PubMed:26876169, PubMed:28662060, PubMed:34804026). Required for the activation of infection response gene irg-1 following P.aeruginosa infection (PubMed:26876169). Required to prevent P.aeruginosa ToxA-mediated lethality (PubMed:26876169). May also function in concert with transcription factor zip-11 to mediate immune responses, independently of the pmk-1/p38 MAPK pathway (PubMed:34804026). May act together with the bZIP transcription factor, zip-2 (PubMed:26876169).SUBUNIT Interacts with transcription factor zip-11.INTERACTION Expressed broadly in somatic tissues including the intestine.DISRUPTION PHENOTYPE RNAi-mediated knockdown reduces overall fat content (PubMed:26505800). Decreases survival upon infection with P.aeruginosa (PubMed:26876169, PubMed:28662060). Reduces induction of expression of infection response gene, irg-1, in response to P.aeruginosa (PubMed:26876169). The decrease in survival upon P.aeruginosa infection on a zip-11 mutant background is abolished by RNAi-mediated knockdown of cebp-2.SIMILARITY Belongs to the bZIP family. C/EBP subfamily. |
| created | [InstanceEdit:9706439] Weiser, JD |
| description | recommendedName: fullName evidence="9"CCAAT/enhancer-binding protein homolog 2 |
| geneName | cebp-2 C48E7.11 |
| identifier | Q8IG69 |
| isSequenceChanged | FALSE |
| keyword | Coiled coil DNA-binding Immunity Innate immunity Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | cebp-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CEBP2_CAEEL |
| sequenceLength | 100 |
| species | [Species:68320] Caenorhabditis elegans |
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No pathways have been reviewed or authored by UniProt:Q8IG69 cebp-2 (9706446)
