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Details on Person UniProt:Q9VPD3-2 Pss
| Class:Id | ReferenceIsoform:9706443 |
|---|---|
| _chainChangeLog | chain:1-498 for 9706443 added on Thu November 5 2020 |
| _displayName | UniProt:Q9VPD3-2 Pss |
| _timestamp | 2023-11-03 18:33:19 |
| chain | chain:1-498 |
| checksum | 617134A5D78F028E |
| comment | FUNCTION Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolaminePATHWAY Phospholipid metabolism; phosphatidylserine biosynthesis.SUBCELLULAR LOCATION Lethal at the first instar larval stage (PubMed:31869331). RNAi-mediated knockdown in salivary glands reduces phosphatidylserine (PS) levels and depletes Akt1 from the plasma membrane contributing to cell growth defects probably by affecting the insulin pathway; causes a shift from phospholipid synthesis to neutral lipid synthesis, which results in ectopic lipid accumulation in third instar larval salivary glands; reduces mitochondrial PS levels thereby impairing mitochondrial protein import and mitochondrial integrity (PubMed:31869331).SIMILARITY Belongs to the phosphatidyl serine synthase family. |
| created | [InstanceEdit:9706439] Weiser, JD |
| description | recommendedName: fullName evidence="6 10"Phosphatidylserine synthase ecNumber evidence="5"2.7.8.29 |
| geneName | Pss l(3)77CDf ptdss1 CG4825 |
| identifier | Q9VPD3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Endoplasmic reticulum Glycoprotein Lipid metabolism Membrane Phospholipid metabolism Reference proteome Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Pss |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PTSS_DROME M9PIC3 |
| sequenceLength | 498 |
| species | [Species:56210] Drosophila melanogaster |
| variantIdentifier | Q9VPD3-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9VPD3-2 Pss (9706443)
