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Details on Person UniProt:Q94230 plp-1
| Class:Id | ReferenceGeneProduct:9706440 |
|---|---|
| _chainChangeLog | chain:1-226 for 9706440 added on Thu November 5 2020 |
| _displayName | UniProt:Q94230 plp-1 |
| _timestamp | 2023-11-03 15:20:41 |
| chain | chain:1-226 |
| checksum | A91A8ADABA72CD67 |
| comment | FUNCTION Probable transcription activator (PubMed:19084000). Binds telomeric DNA containing repeats of the sequence, 5'-TTAGGC-3' (PubMed:16267406). Binds to end-1 promoter, activating end-1 expression, which is required for endoderm specification during embryonic development (PubMed:19084000).SUBCELLULAR LOCATION localizes to nuclei of interphase cells throughout early embryogenesis. Localizes to the nucleus in a lit-1 dependent manner. Transiently asymmetrically localizes during telophase of the dividing EMS cell with higher levels in the future E cell nucleus and low or undetectable levels in that of the MS cell.DEVELOPMENTAL STAGE First expressed in blastomeres at the two cell stage of embryogenesis (PubMed:19084000). Also expressed in germline-specific P granules of early embryos (PubMed:19084000).DISRUPTION PHENOTYPE Sterile due to lack of oocytes (PubMed:25439098). Defective locomotion, marked by a 3-fold reduction in speed (PubMed:25439098). RNAi-mediated knockdown causes embryonic lethality (PubMed:19084000). RNAi-mediated knockdown substantially reduces expression of end-1 (PubMed:19084000). RNAi-mediated knockdown abolishes formation of endoderm in 3% of embryos and in 35% of embryos on a mom-5 mutant background (PubMed:19084000).SIMILARITY Belongs to the PUR DNA-binding protein family. |
| created | [InstanceEdit:9706439] Weiser, JD |
| description | recommendedName: fullName evidence="5"Transcriptional activator plp-1 alternativeName: fullName evidence="4"Pur-alpha-like protein 1 |
| geneName | plp-1 F45E4.2 |
| identifier | Q94230 |
| isSequenceChanged | FALSE |
| keyword | Activator Chromosome DNA-binding Nucleus Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | plp-1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | PLP1_CAEEL |
| sequenceLength | 226 |
| species | [Species:68320] Caenorhabditis elegans |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q94230 plp-1 (9706440)
