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Details on Person Internalization of ubiquitinated FLT3

Class:IdBlackBoxEvent:9706364
_displayNameInternalization of ubiquitinated FLT3
_doReleaseTRUE
_timestamp2020-11-06 20:54:55
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment[Compartment:876] plasma membrane
[Compartment:74700] endosome membrane
created[InstanceEdit:9706366] Rothfels, Karen, 2020-11-04
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input[Complex:9706245] Ub-pY FLT3:FLT3LG dimer [plasma membrane] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9706100] Flt3-dependent transformation by inactivating c-Cbl mutations in AML
[LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes
[LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
modified[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameInternalization of ubiquitinated FLT3
output[Complex:9706242] Ub-pY FLT3:FLT3LG dimer [endosome membrane] [Homo sapiens]
precedingEvent
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9706367] R-HSA-9706364.2
summation[Summation:9706365] E3 ligase- mediated ubiquitination of FLT3 leads to its inte...
(hasEvent)[Pathway:9706369] Negative regulation of FLT3 [Homo sapiens]
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