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Details on Person Active FLT3 binds to CBL

Class:Id	Reaction:9706293
_displayName	Active FLT3 binds to CBL
_doRelease	TRUE
_timestamp	2020-11-06 20:52:36
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9706292] Rothfels, Karen, 2020-11-04
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[Complex:9604751] Active FLT3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9706100] Flt3-dependent transformation by inactivating c-Cbl mutations in AML [LiteratureReference:9706063] CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes [LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
modified	[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active FLT3 binds to CBL
output	[Complex:9706252] active FLT3:CBL [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9604767] FLT3LG dimer:FLT3 dimer autophosphorylates [Homo sapiens] [Reaction:8854736] FLT3LG dimer:FLT3 binds FLT3 [Homo sapiens]
regulatedBy	[PositiveRegulation:9706294] Positive regulation by 'active FLT3:SH2B3 [plasma membrane]' [PositiveRegulation:9706295] Positive regulation by 'active FLT3:SLA [plasma membrane]' [PositiveRegulation:9706291] Positive regulation by 'active FLT3:SLA2 [plasma membrane]'
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9706297] R-HSA-9706293.2
summation	[Summation:9706296] Active FLT3 is bound by the E3 ubiquitin protein ligase CBL....
(hasEvent)	[Pathway:9706369] Negative regulation of FLT3 [Homo sapiens]
(precedingEvent)	[Reaction:9706350] FLT3 phosphorylates CBL [Homo sapiens]
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No pathways have been reviewed or authored by Active FLT3 binds to CBL (9706293)