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Details on Person CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes
| Class:Id | LiteratureReference:9706063 |
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| _displayName | CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes |
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| _timestamp | 2020-11-04 12:14:48 |
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| author | [Person:9691016] Reindl, Carola
[Person:9706070] Quentmeier, Hilmar
[Person:9706068] Petropoulos, Konstantin
[Person:9706065] Greif, Philipp A
[Person:9706069] Benthaus, Tobias
[Person:9706071] Argiropoulos, Bob
[Person:9706064] Mellert, Gudrun
[Person:9691019] Vempati, Sridhar
[Person:9649391] Duyster, Justus
[Person:8867930] Buske, Christian
[Person:8867573] Bohlander, Stefan K
[Person:9706066] Humphries, Keith R
[Person:6791173] Hiddemann, Wolfgang
[Person:9691017] Spiekermann, Karsten |
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| created | [InstanceEdit:9706067] Rothfels, Karen, 2020-11-04 |
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| journal | Clin Cancer Res |
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| pages | 2238-47 |
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| pubMedIdentifier | 19276253 |
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| title | CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes |
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| volume | 15 |
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| year | 2009 |
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| (literatureReference) | [Reaction:9706293] Active FLT3 binds to CBL [Homo sapiens]
[Reaction:9706350] FLT3 phosphorylates CBL [Homo sapiens]
[BlackBoxEvent:9706354] Ubiquitination of FLT3 [Homo sapiens]
[FailedReaction:9706356] CBL mutants don't ubiquitinate FLT3 [Homo sapiens]
[BlackBoxEvent:9706364] Internalization of ubiquitinated FLT3 [Homo sapiens]
[Pathway:9706377] FLT3 signaling by CBL mutants [Homo sapiens]
[EntityWithAccessionedSequence:9706176] CBL del366-477 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9706179] CBL E366_Q409del [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9706183] CBL del366-380 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:9706203] CBL R420G [cytosol] [Homo sapiens] |
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