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Details on Person nsp15 cleaves viral poly(U)-RNA

Class:IdBlackBoxEvent:9705961
_displayNamensp15 cleaves viral poly(U)-RNA
_doReleaseTRUE
_timestamp2022-08-18 02:19:37
authored[InstanceEdit:9692648] Shamovsky, Veronica, 2020-06-25
catalystActivity[CatalystActivity:9705953] RNA endonuclease activity producing 3'-phosphomonoesters, hydrolytic mechanism of RTC [double membrane vesicle viral factory outer membrane]
compartment[Compartment:9684675] double membrane vesicle viral factory outer membrane
[Compartment:459] cytoplasm
created[InstanceEdit:9705954] Shamovsky, Veronica, 2020-11-03
disease[Disease:9678120] severe acute respiratory syndrome
edited[InstanceEdit:9796665] Shamovsky, Veronica, 2022-08-11
input[DefinedSet:9693595] SARS-CoV-1 dsRNA with poly(U)-contaiining (-) strand [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus]
isChimericFALSE
literatureReference[LiteratureReference:9683389] Mutational analysis of the SARS virus Nsp15 endoribonuclease: identification of residues affecting hexamer formation
[LiteratureReference:9683204] Structural and functional analyses of the severe acute respiratory syndrome coronavirus endoribonuclease Nsp15
modified[InstanceEdit:9709088] Shamovsky, Veronica, 2020-12-08
[InstanceEdit:9709090] Shamovsky, Veronica, 2020-12-08
[InstanceEdit:9710713] Shamovsky, Veronica, 2021-01-05
[InstanceEdit:9713616] Shamovsky, Veronica, 2021-01-27
[InstanceEdit:9796135] Shamovsky, Veronica, 2022-08-05
[InstanceEdit:9796527] Shamovsky, Veronica, 2022-08-10
[InstanceEdit:9796658] Shamovsky, Veronica, 2022-08-11
[InstanceEdit:9815493] Shamovsky, Veronica, 2022-08-18
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namensp15 cleaves viral poly(U)-RNA
output[SimpleEntity:9705955] 3'-UMP [cytosol]
[Complex:9682692] SARS coronavirus gRNA with secondary structure:RTC:nascent RNA minus strand [double membrane vesicle viral factory outer membrane] [Human SARS coronavirus]
precedingEvent
relatedSpecies[Species:9678119] Human SARS coronavirus
releaseDate2022-09-14
reviewed[InstanceEdit:9713569] D'Eustachio, Peter, 2021-01-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9705965] R-HSA-9705961.2
summation[Summation:9705958] Nonstructural protein 15 (nsp15) of severe acute respiratory...
(hasEvent)[Pathway:9692916] SARS-CoV-1 activates/modulates innate immune responses [Homo sapiens]
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No pathways have been reviewed or authored by nsp15 cleaves viral poly(U)-RNA (9705961)