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Details on Person AR binds AR agonists

Class:Id	Reaction:9705926
_displayName	AR binds AR agonists
_doRelease	TRUE
_timestamp	2022-05-10 17:54:21
authored	[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03
edited	[InstanceEdit:9705894] Jassal, Bijay, 2020-11-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input	[Complex:9705922] HSP90:ATP:FKBP4:PTGES3:AR [cytosol] [Homo sapiens] [DefinedSet:9705896] AR agonists [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9706786] Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone [LiteratureReference:9706758] Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone [LiteratureReference:9706804] Molecular mechanisms of androgen action--a historical perspective [LiteratureReference:9706799] Clinical review 138: Anabolic-androgenic steroid therapy in the treatment of chronic diseases [LiteratureReference:9706745] Therapeutic effects of anabolic androgenic steroids on chronic diseases associated with muscle wasting [LiteratureReference:9706727] Wasting away: How to treat cachexia and muscle wasting in chronic disease? [LiteratureReference:9706736] A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids [LiteratureReference:9706754] Androgen Treatment in Adolescent Males With Hypogonadism [LiteratureReference:9706777] Hormonal profile of menopausal women receiving androgen replacement therapy: a meta-analysis [LiteratureReference:9706759] Acquired and hereditary forms of recurrent angioedema: Update of treatment [LiteratureReference:9706748] Androgens and endometrium: New insights and new targets [LiteratureReference:9706732] Androgens, oestrogens and endometrium: a fine balance between perfection and pathology [LiteratureReference:9706784] Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [LiteratureReference:9706762] [Safety of long-term replacement hormonal therapy in patients with erectile dysfunction and androgen deficiency] [LiteratureReference:9706800] Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in Aging Male: Therapeutic Implications [LiteratureReference:9706792] Impact of androgen receptor expression in fluoxymesterone-treated estrogen receptor-positive metastatic breast cancer refractory to contemporary hormonal therapy [LiteratureReference:9706746] Androgen Receptor in Breast Cancer: From Bench to Bedside [LiteratureReference:9706734] Androgen Receptor Function and Androgen Receptor-Targeted Therapies in Breast Cancer: A Review
modified	[InstanceEdit:9706780] Jassal, Bijay, 2020-11-09 [InstanceEdit:9726677] Jassal, Bijay, 2021-04-08 [InstanceEdit:9726813] Jassal, Bijay, 2021-04-12 [InstanceEdit:9773229] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10 [InstanceEdit:9773858] Matthews, Lisa, 2022-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AR binds AR agonists
output	[Complex:9705910] HSP90:ATP:FKBP4:PTGES3:AR:AR agonists [cytosol] [Homo sapiens]
reactionType	[DrugActionType:9725061] Agonist
releaseDate	2022-06-09
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9705946] R-HSA-9705926.2
summation	[Summation:9706750] Endogenous androgens such as testosterone and dihydrotestost...
(hasEvent)	[Pathway:3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand [Homo sapiens]
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No pathways have been reviewed or authored by AR binds AR agonists (9705926)