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Details on Person SRD5A2 binds SRD5A2 inhibitors

Class:Id	Reaction:9705794
_displayName	SRD5A2 binds SRD5A2 inhibitors
_doRelease	TRUE
_timestamp	2022-05-10 17:57:38
authored	[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9705803] Jassal, Bijay, 2020-10-30
edited	[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input	[EntityWithAccessionedSequence:469664] SRD5A2 [endoplasmic reticulum membrane] [Homo sapiens] [DefinedSet:9705798] SRD5A2 inhibitors [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9705809] Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding [LiteratureReference:9705811] A model for the turnover of dihydrotestosterone in the presence of the irreversible 5 alpha-reductase inhibitors GI198745 and finasteride [LiteratureReference:9705787] Therapeutic options in the treatment of benign prostatic hyperplasia [LiteratureReference:9705764] Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride [LiteratureReference:9705795] Dutasteride: a review of its use in the management of prostate disorders [LiteratureReference:9705810] Finasteride for benign prostatic hyperplasia [LiteratureReference:9705792] An overview on 5alpha-reductase inhibitors [LiteratureReference:9705769] Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid [LiteratureReference:9705800] Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and hyperpigmentary skin disorders [LiteratureReference:9705763] [Mechanism of azelaic acid action in acne]
modified	[InstanceEdit:9773229] Matthews, Lisa, 2022-05-03 [InstanceEdit:9773839] Matthews, Lisa, 2022-05-10 [InstanceEdit:9773858] Matthews, Lisa, 2022-05-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SRD5A2 binds SRD5A2 inhibitors
output	[Complex:9705766] SRD5A2:SRD5A2 inhibitors [endoplasmic reticulum membrane] [Homo sapiens]
releaseDate	2022-06-09
reviewed	[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9705814] R-HSA-9705794.2
summation	[Summation:9705813] The conversion of testosterone (TEST) to the most potent and...
(hasEvent)	[Pathway:193048] Androgen biosynthesis [Homo sapiens]
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No pathways have been reviewed or authored by SRD5A2 binds SRD5A2 inhibitors (9705794)