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Details on Person SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7

Class:Id	BlackBoxEvent:9705738
_displayName	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
_doRelease	TRUE
_timestamp	2020-12-12 08:33:37
authored	[InstanceEdit:9705725] May, Bruce, 2020-10-24
catalystActivity	[CatalystActivity:9705733] ubiquitin protein ligase activity of SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane]
compartment	[Compartment:24337] endocytic vesicle membrane
created	[InstanceEdit:9705735] May, Bruce, 2020-10-30
edited	[InstanceEdit:9705725] May, Bruce, 2020-10-24
input	[Complex:9705723] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] [Homo sapiens] [Complex:8953915] Ub:UBE2D1,2,3 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9707890] Site-specific ubiquitination determines lysosomal sorting and signal attenuation of the granulocyte colony-stimulating factor receptor [LiteratureReference:9707892] Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor
modified	[InstanceEdit:9707985] May, Bruce, 2020-11-21 [InstanceEdit:9708232] May, Bruce, 2020-11-26 [InstanceEdit:9709305] May, Bruce, 2020-12-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
output	[DefinedSet:877267] SOCS-1 and SOCS-3 [cytosol] [Homo sapiens] [DefinedSet:877267] SOCS-1 and SOCS-3 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180528] CUL5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180528] CUL5 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180551] ELOB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180551] ELOB [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180535] ELOC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:180535] ELOC [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8863132] RNF7 (RBX2) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8863132] RNF7 (RBX2) [cytosol] [Homo sapiens] [Complex:9707902] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] [Homo sapiens]
precedingEvent	[Reaction:9705729] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 [Homo sapiens] [BlackBoxEvent:9705726] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 is endocytosed [Homo sapiens]
releaseDate	2021-03-23
reviewed	[InstanceEdit:9709304] Touw, Ivo P, 2020-12-12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9705749] R-HSA-9705738.2
summation	[Summation:9707966] A ubiquitin E3 ligase complex assembled by SOCS3 or SOCS1 po...
(hasEvent)	[Pathway:9705462] Inactivation of CSF3 (G-CSF) signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9707977] CSF3 dimer:2xK48polyUb-K655,p-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-Y-SYK:p-HCK:p-TYK2 translocates from the endocytic vesicle membrane to the lysosomal membrane [Homo sapiens]
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No pathways have been reviewed or authored by SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (9705738)