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Details on Person MPP5 binds SARS-CoV-2 E pentamer

Class:Id	Reaction:9705681
_displayName	MPP5 binds SARS-CoV-2 E pentamer
_doRelease	TRUE
_timestamp	2022-03-01 03:08:38
authored	[InstanceEdit:9757087] Shamovsky, Veronica, 2021-10-27
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:9705656] Shamovsky, Veronica, 2020-10-28
disease	[Disease:9683912] COVID-19
edited	[InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18
inferredFrom	[Reaction:9689608] MPP5 binds SARS-CoV-1 E pentamer [Homo sapiens]
input	[EntityWithAccessionedSequence:9689606] MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] [Homo sapiens] [Complex:9698418] Ub-3xPalmC-E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane] [Severe acute respiratory syndrome coronavirus 2]
isChimeric	FALSE
literatureReference	[LiteratureReference:9696717] The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis [LiteratureReference:9704980] Comparing the binding properties of peptides mimicking the Envelope protein of SARS-CoV and SARS-CoV-2 to the PDZ domain of the tight junction-associated PALS1 protein [LiteratureReference:9704978] Improved binding of SARS-CoV-2 Envelope protein to tight junction-associated PALS1 could play a key role in COVID-19 pathogenesis [LiteratureReference:9754606] Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
modified	[InstanceEdit:9754607] Shamovsky, Veronica, 2021-09-30 [InstanceEdit:9765902] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9766200] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9766341] Shamovsky, Veronica, 2022-02-18 [InstanceEdit:9767625] Shamovsky, Veronica, 2022-03-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MPP5 binds SARS-CoV-2 E pentamer
output	[Complex:9705682] MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9694294] E pentamer is transported to the Golgi [Homo sapiens] [Reaction:9694452] Protein E forms a homopentamer [Homo sapiens]
relatedSpecies	[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate	2022-03-23
reviewed	[InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9705689] R-HSA-9705681.2
summation	[Summation:9705685] This SARS-CoV-2 event was manually inferred from the interac...
(hasEvent)	[Pathway:9705677] SARS-CoV-2 targets PDZ proteins in cell-cell junction [Homo sapiens]
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No pathways have been reviewed or authored by MPP5 binds SARS-CoV-2 E pentamer (9705681)