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Details on Person HMGCR dimer binds statins

Class:IdReaction:9705584
_displayNameHMGCR dimer binds statins
_doReleaseTRUE
_timestamp2025-10-23 21:30:41
authored[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27
edited[InstanceEdit:9705585] Jassal, Bijay, 2020-10-27
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input[Complex:191277] HMGCR dimer [endoplasmic reticulum membrane] [Homo sapiens]
[DefinedSet:9705575] statins [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9705598] Binding thermodynamics of statins to HMG-CoA reductase
[LiteratureReference:9705573] An Atomic-Level Perspective of HMG-CoA-Reductase: The Target Enzyme to Treat Hypercholesterolemia
[LiteratureReference:9705579] Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase
[LiteratureReference:9705572] Structural mechanism for statin inhibition of HMG-CoA reductase
modified[InstanceEdit:9705611] Jassal, Bijay, 2020-10-27
[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27
[InstanceEdit:9773229] Matthews, Lisa, 2022-05-03
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
[InstanceEdit:9773858] Matthews, Lisa, 2022-05-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9969889] D'Eustachio, Peter, 2025-10-23
nameHMGCR dimer binds statins
output[Complex:9705595] HMGCR dimer:statins [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent
releaseDate2022-06-09
reviewed[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9705609] R-HSA-9705584.3
summation[Summation:9705590] Dimeric 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HM...
(hasEvent)[Pathway:9969896] Lanosterol biosynthesis [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971943] Update Tracker - [Reaction:9705584] HMGCR dimer binds statins - v95:[removeLiteratureReference]
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No pathways have been reviewed or authored by HMGCR dimer binds statins (9705584)