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Details on Person TBK1, IKBKE are autophosphorylated at Ser172

Class:Id	Reaction:9705320
_displayName	TBK1, IKBKE are autophosphorylated at Ser172
_doRelease	TRUE
_timestamp	2023-05-18 15:08:09
authored	[InstanceEdit:9710238] Shamovsky, Veronica, 2020-12-25
catalystActivity	[CatalystActivity:9705335] protein serine/threonine kinase activity of viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
catalystActivityReference	[CatalystActivityReference:9705331] protein serine/threonine kinase activity of dsRNA:RIG-I/MDA5:IPS-1:TRAF2/TRAF6:TANK:2xTBK1/IKKi [mitochondrial outer membrane] Crystal structure and mechanism of activation of TANK-binding kinase 1
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:9705319] Shamovsky, Veronica, 2020-10-22
edited	[InstanceEdit:9716568] Shamovsky, Veronica, 2021-02-22
input	[SimpleEntity:113592] ATP [cytosol] [Complex:9705133] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2xIKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:5362581] Crystal structure and mechanism of activation of TANK-binding kinase 1 [LiteratureReference:2408458] Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation [LiteratureReference:9705315] IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
modified	[InstanceEdit:9710998] Shamovsky, Veronica, 2021-01-06 [InstanceEdit:9713626] Shamovsky, Veronica, 2021-01-27 [InstanceEdit:9715437] Shamovsky, Veronica, 2021-02-17 [InstanceEdit:9716563] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9716569] Shamovsky, Veronica, 2021-02-22 [InstanceEdit:9727969] Shamovsky, Veronica, 2021-04-19 [InstanceEdit:9765940] Shamovsky, Veronica, 2022-02-17 [InstanceEdit:9768018] Shamovsky, Veronica, 2022-03-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9835850] Shamovsky, Veronica, 2023-05-18
name	TBK1, IKBKE are autophosphorylated at Ser172
output	[Complex:9710999] viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:2x(TBK1/IKBKE) [mitochondrial outer membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9705137] TBK1 or IKBKE forms homodimers [Homo sapiens] [Reaction:918225] TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 [Homo sapiens]
regulatedBy	[NegativeRegulation:9705329] Negative regulation by 'TBK1:pp1ab-nsp13 [cytosol]'
regulationReference	[RegulationReference:9705326] Negative regulation by 'TBK1:pp1ab-nsp13 [cytosol]' Evasion of Type I Interferon by SARS-CoV-2
relatedSpecies	[Species:5621375] Hepatitis C Virus [Species:9013948] Measles virus [Species:5617433] Rotavirus [Species:9031716] Influenza A virus [Species:9681683] Severe acute respiratory syndrome coronavirus 2 [Species:9717528] Human respiratory syncytial virus A
releaseDate	2021-03-23
reviewed	[InstanceEdit:9713624] D'Eustachio, Peter, 2021-01-27 [InstanceEdit:9727967] Ramos, Carlos H I, 2021-04-19 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9705339] R-HSA-9705320.4
summation	[Summation:9705332] Viral nucleic acids are sensed by cellular pattern-recogniti...
(hasEvent)	[Pathway:918233] TRAF3-dependent IRF activation pathway [Homo sapiens] [Pathway:9705671] SARS-CoV-2 activates/modulates innate and adaptive immune responses [Homo sapiens]
(precedingEvent)	[Reaction:9724201] PPM1A, PPM1B dephosphorylate TBK1 or IKBKE [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9774950] Update Tracker - [Reaction:9705320] TBK1, IKBKE are autophosphorylated at Ser172 - v80:[addRegulator]
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No pathways have been reviewed or authored by TBK1, IKBKE are autophosphorylated at Ser172 (9705320)