Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Viral infection and stimulation of some pattern-recognition ...
| Class:Id | Summation:9705094 |
|---|---|
| _displayName | Viral infection and stimulation of some pattern-recognition ... |
| _timestamp | 2023-01-24 20:32:17 |
| created | [InstanceEdit:9705081] Shamovsky, Veronica, 2020-10-21 |
| literatureReference | [LiteratureReference:9705074] Evasion of Type I Interferon by SARS-CoV-2 [LiteratureReference:5362611] Structure and ubiquitination-dependent activation of TANK-binding kinase 1 [LiteratureReference:9705013] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing [LiteratureReference:9762567] SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms |
| modified | [InstanceEdit:9762572] Stephan, Ralf, 2022-01-27 [InstanceEdit:9825265] Shamovsky, Veronica, 2023-01-24 |
| text | Viral infection and stimulation of some pattern-recognition receptors such as the toll-like receptor 3 (TLR3) in the endosomes or the RIG-I-like receptors in the cytosol leads to the activation of the IKK-related TANK binding kinase 1 (TBK1). TBK1 in turn phosphorylates the interferon regulatory factor 3 (IRF3/7). The phosphorylated IRF3 forms a dimer and translocates to the nucleus, activating the transcription of type I IFN (IFN-I) genes (Tu D et al. 2013). Non-structural protein 13 (nsp13) originated from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was found to interact with TBK1 in human embryonic kidney 293 (HEK293) cells, that were co-transfected with plasmids expressing TBK1 and tagged nsp13 (Xia H et al. 2020; Gordon DE et al. 2020). Viral nsp13 antagonized IFN-I production in HEK293 cells by binding to TBK1 and suppressing phosphorylation of TBK1 (Xia H et al. 2020; Vazquez et al, 2021). |
| (summation) | [Reaction:9705082] SARS-CoV-2 nsp13 binds TBK1 [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Viral infection and stimulation of some pattern-recognition ... (9705094)
