Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person CASR binds CASR agonists

Class:IdReaction:9703895
_displayNameCASR binds CASR agonists
_doReleaseTRUE
_timestamp2022-05-10 17:55:02
authored[InstanceEdit:9724665] Jassal, Bijay, 2021-03-25
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:9703827] Jassal, Bijay, 2020-10-07
definitionAgonist
edited[InstanceEdit:9757169] Jassal, Bijay, 2021-10-27
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
input[EntityWithAccessionedSequence:420719] CASR [plasma membrane] [Homo sapiens]
[DefinedSet:9703850] CASR agonists [extracellular region]
isChimericFALSE
literatureReference[LiteratureReference:9703836] Pharmacology of AMG 416 (Velcalcetide), a novel peptide agonist of the calcium-sensing receptor, for the treatment of secondary hyperparathyroidism in hemodialysis patients
[LiteratureReference:9703892] Velcalcetide (AMG 416), a novel peptide agonist of the calcium-sensing receptor, reduces serum parathyroid hormone and FGF23 levels in healthy male subjects
[LiteratureReference:9703848] A novel calcimimetic agent, evocalcet (MT-4580/KHK7580), suppresses the parathyroid cell function with little effect on the gastrointestinal tract or CYP isozymes in vivo and in vitro
[LiteratureReference:9703898] The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis
[LiteratureReference:9703833] Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis
[LiteratureReference:9703872] Cinacalcet hydrochloride treatment significantly improves all-cause and cardiovascular survival in a large cohort of hemodialysis patients
[LiteratureReference:9703844] PTH-dependence of the effectiveness of cinacalcet in hemodialysis patients with secondary hyperparathyroidism
modified[InstanceEdit:9773229] Matthews, Lisa, 2022-05-03
[InstanceEdit:9773839] Matthews, Lisa, 2022-05-10
[InstanceEdit:9773858] Matthews, Lisa, 2022-05-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameCASR binds CASR agonists
output[Complex:9703908] CASR:CASR agonists [plasma membrane] [Homo sapiens]
releaseDate2022-06-09
reviewed[InstanceEdit:9767610] Huddart, Rachel, 2022-03-01
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9703917] R-HSA-9703895.2
summation[Summation:9703841] Patients with chronic kidney disease often develop secondary...
(hasEvent)[Pathway:420499] Class C/3 (Metabotropic glutamate/pheromone receptors) [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by CASR binds CASR agonists (9703895)
Follow Reactome