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Details on Person SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants

Class:Id	Reaction:9703441
_displayName	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
_doRelease	TRUE
_timestamp	2020-11-06 20:55:24
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity	[CatalystActivity:9703425] guanyl-nucleotide exchange factor activity of p-Y FLT3 fusions:GRB2:SOS1 [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[Complex:109796] p21 RAS:GDP [plasma membrane] [Homo sapiens] [SimpleEntity:29438] GTP [cytosol]
literatureReference	[LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy [LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3? [LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
modified	[InstanceEdit:9703712] Rothfels, Karen, 2020-10-06 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants
output	[Complex:109783] p21 RAS:GTP [plasma membrane] [Homo sapiens] [SimpleEntity:29420] GDP [cytosol]
precedingEvent	[Reaction:9703430] FLT3 fusions:GRB2 bind SOS1 [Homo sapiens] [Reaction:9703442] Phosphorylated FLT3 fusions bind GRB2 [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9703444] R-HSA-9703441.2
summation	[Summation:9703412] SOS1-mediated nucleotide exchange on RAS is presumed to occu...
(hasEvent)	[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
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No pathways have been reviewed or authored by SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants (9703441)