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Details on Person FLT3 fusions recruit PIK3R1 through phosphorylated GAB2

Class:Id	Reaction:9703439
_displayName	FLT3 fusions recruit PIK3R1 through phosphorylated GAB2
_doRelease	TRUE
_timestamp	2020-11-06 20:54:06
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
inferredFrom	[Reaction:9607226] Active Flt3:Grb2:p-Y-Gab2 binds Pik3r1 [Mus musculus]
input	[EntityWithAccessionedSequence:74789] PIK3R1 [cytosol] [Homo sapiens] [Complex:9703356] p-Y FLT3 fusions:GRB2:p-Y GAB2 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy [LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation [LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3? [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9697911] p85 subunit of PI3 kinase does not bind to human Flt3 receptor, but associates with SHP2, SHIP, and a tyrosine-phosphorylated 100-kDa protein in Flt3 ligand-stimulated hematopoietic cells [LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival
modified	[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT3 fusions recruit PIK3R1 through phosphorylated GAB2
output	[Complex:9703358] p-Y FLT fusions:GRB2:p-Y GAB2:PI3KR1 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9703438] FLT3 fusions phosphorylate GAB2 [Homo sapiens] [Reaction:9703440] FLT3 fusions:GRB2 bind GAB2 [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9703449] R-HSA-9703439.2
summation	[Summation:9703423] FLT3 fusions signal through the PI3K/AKT pathway as assessed...
(hasEvent)	[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
(precedingEvent)	[Reaction:9703434] FLT3 fusions recruit PIK3CA through PIK3R1 [Homo sapiens]
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