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Details on Person FLT3 fusions phosphorylate GAB2

Class:IdReaction:9703438
_displayNameFLT3 fusions phosphorylate GAB2
_doReleaseTRUE
_timestamp2020-11-06 20:54:00
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity[CatalystActivity:9703426] protein tyrosine kinase activity of p-Y FLT3 fusions:GRB2:GAB2 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease[Disease:1500689] cancer
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input[Complex:9703352] p-Y FLT3 fusions:GRB2:GAB2 [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
modified[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFLT3 fusions phosphorylate GAB2
output[Complex:9703356] p-Y FLT3 fusions:GRB2:p-Y GAB2 [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9703448] R-HSA-9703438.2
summation[Summation:9703418] GAB2 is presumed to be phosphorylated downstream of active F...
(hasEvent)[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
(precedingEvent)[Reaction:9703439] FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 [Homo sapiens]
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No pathways have been reviewed or authored by FLT3 fusions phosphorylate GAB2 (9703438)