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Details on Person FLT3 fusion dimers autophosphorylate

Class:IdReaction:9703437
_displayNameFLT3 fusion dimers autophosphorylate
_doReleaseTRUE
_timestamp2020-11-06 20:53:55
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
catalystActivity[CatalystActivity:9703427] protein tyrosine kinase activity of FLT3 fusion dimers [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease[Disease:1500689] cancer
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input[CandidateSet:9703409] FLT3 fusion dimers [cytosol] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9703225] FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation
[LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy
[LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3?
[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
[LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
modified[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFLT3 fusion dimers autophosphorylate
output[CandidateSet:9703372] p-Y FLT3 fusion dimers [cytosol] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9703447] R-HSA-9703437.2
summation[Summation:9703417] After ligand-independent dimerization, FLT3 fusion proteins ...
(hasEvent)[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9703435] FLT3 fusions activate STAT5 [Homo sapiens]
[Reaction:9703442] Phosphorylated FLT3 fusions bind GRB2 [Homo sapiens]
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No pathways have been reviewed or authored by FLT3 fusion dimers autophosphorylate (9703437)
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