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Details on Person Ligand-independent dimerization of FLT3 fusion proteins

Class:Id	Reaction:9703433
_displayName	Ligand-independent dimerization of FLT3 fusion proteins
_doRelease	TRUE
_timestamp	2020-11-06 20:55:03
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[CandidateSet:9703345] FLT3 fusion proteins [cytosol] [Homo sapiens] [CandidateSet:9703345] FLT3 fusion proteins [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9703236] Myeloid neoplasms with eosinophilia [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9703167] Transgenic mice expressing Tel-FLT3, a constitutively activated form of FLT3, develop myeloproliferative disease [LiteratureReference:9703225] FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation [LiteratureReference:9703277] Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3 [LiteratureReference:9703222] ETV6-FLT3 fusion gene-positive, eosinophilia-associated myeloproliferative neoplasm successfully treated with sorafenib and allogeneic stem cell transplant [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 [LiteratureReference:9703256] A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia [LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3? [LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy [LiteratureReference:9703211] Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia [LiteratureReference:9703169] Two myeloid leukemia cases with rare FLT3 fusions [LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
modified	[InstanceEdit:9703457] Rothfels, Karen, 2020-10-06 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ligand-independent dimerization of FLT3 fusion proteins
output	[CandidateSet:9703409] FLT3 fusion dimers [cytosol] [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9703454] R-HSA-9703433.2
summation	[Summation:9703413] In addition to internal tandem duplications and activating p...
(hasEvent)	[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
(precedingEvent)	[Reaction:9703437] FLT3 fusion dimers autophosphorylate [Homo sapiens]
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No pathways have been reviewed or authored by Ligand-independent dimerization of FLT3 fusion proteins (9703433)