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Details on Person p-STAT5 dissociates from FLT3 fusion proteinsp-

Class:Id	BlackBoxEvent:9703432
_displayName	p-STAT5 dissociates from FLT3 fusion proteinsp-
_doRelease	TRUE
_timestamp	2020-11-06 20:56:09
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[Complex:9703359] p-Y FLT3 fusions:p-STAT5 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy [LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 [LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications [LiteratureReference:9697879] STAT5 in Cancer and Immunity
modified	[InstanceEdit:9704328] Rothfels, Karen, 2020-10-07 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-STAT5 dissociates from FLT3 fusion proteinsp-
output	[DefinedSet:507929] p-STAT5A, p-STAT5B [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9703435] FLT3 fusions activate STAT5 [Homo sapiens] [Reaction:9703437] FLT3 fusion dimers autophosphorylate [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9703453] R-HSA-9703432.2
summation	[Summation:9703422] Phosphorylated STAT5 is released from the receptor to fulfil...
(hasEvent)	[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
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No pathways have been reviewed or authored by p-STAT5 dissociates from FLT3 fusion proteinsp- (9703432)