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Details on Person FLT3 fusions:GRB2 bind SOS1

Class:IdReaction:9703430
_displayNameFLT3 fusions:GRB2 bind SOS1
_doReleaseTRUE
_timestamp2020-11-06 20:54:11
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment[Compartment:70101] cytosol
created[InstanceEdit:9703431] Rothfels, Karen, 2020-10-06
disease[Disease:1500689] cancer
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input[Complex:9703378] p-Y FLT3 fusion dimers:GRB2 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:64847] SOS1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9703191] A constitutively active SPTBN1-FLT3 fusion in atypical chronic myeloid leukemia is sensitive to tyrosine kinase inhibitors and immunotherapy
[LiteratureReference:9703263] A novel t(3;13)(q13;q12) translocation fusing FLT3 with GOLGB1: toward myeloid/lymphoid neoplasms with eosinophilia and rearrangement of FLT3?
[LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
[LiteratureReference:9703182] The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
[LiteratureReference:9697839] FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
modified[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFLT3 fusions:GRB2 bind SOS1
output[Complex:9703349] p-Y FLT3 fusions:GRB2:SOS1 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9703452] R-HSA-9703430.2
summation[Summation:9703415] Activated FTL3 fusion mutants have been shown to signal thro...
(hasEvent)[Pathway:9703465] Signaling by FLT3 fusion proteins [Homo sapiens]
(precedingEvent)[Reaction:9703441] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants [Homo sapiens]
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No pathways have been reviewed or authored by FLT3 fusions:GRB2 bind SOS1 (9703430)