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Details on Person After ligand-independent dimerization, FLT3 fusion proteins ...

Class:IdSummation:9703417
_displayNameAfter ligand-independent dimerization, FLT3 fusion proteins ...
_timestamp2020-10-07 18:27:22
created[InstanceEdit:9703419] Rothfels, Karen, 2020-10-06
modified[InstanceEdit:9704328] Rothfels, Karen, 2020-10-07
textAfter ligand-independent dimerization, FLT3 fusion proteins are trans-autophosophorylated on tyrosine residues, activating downstream signaling through PI3K/AKT, MAP kinase and STAT5 pathways (Vu et al, 2006; Grand et al, 2007; Vu et al, 2009; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Roonstrand, 2019).
(summation)[Reaction:9703437] FLT3 fusion dimers autophosphorylate [Homo sapiens]
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