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Details on Person The 110 kDa catalytic subunit of PI3K is likely recruited to...
| Class:Id | Summation:9703416 |
|---|---|
| _displayName | The 110 kDa catalytic subunit of PI3K is likely recruited to... |
| _timestamp | 2020-10-06 15:18:22 |
| created | [InstanceEdit:9703419] Rothfels, Karen, 2020-10-06 |
| text | The 110 kDa catalytic subunit of PI3K is likely recruited to FLT3 fusions through interaction with the p85 regulatory subunit, as is the case for the wild-type receptor. GAB2-mediated conformational changes in the p85 regulatory subunit stimulate interaction with p110, and promote PI3K/AKT signaling downstream of activated FLT3 (Zhang et al, 1999; Zhang et al, 2000; Vu et al, 2007; Masson et al, 2009; Grand et al, 2007; Troadec et al, 2017; Chonabayashi et al, 2013; reviewed in Kazi and Ronnstrand, 2019). |
| (summation) | [Reaction:9703434] FLT3 fusions recruit PIK3CA through PIK3R1 [Homo sapiens] |
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No pathways have been reviewed or authored by The 110 kDa catalytic subunit of PI3K is likely recruited to... (9703416)
