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Details on Person The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation

Class:Id	LiteratureReference:9703182
_displayName	The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
_timestamp	2020-10-06 15:09:20
author	[Person:9703183] Vu, Hoang Anh [Person:9703179] Xinh, Phan Thi [Person:9703181] Kano, Yasuhiko [Person:9703180] Tokunaga, Katsushi [Person:6788196] Sato, Yuko
created	[InstanceEdit:9703184] Rothfels, Karen, 2020-10-06
pages	308-13
pubMedIdentifier	19345670
title	The juxtamembrane domain in ETV6/FLT3 is critical for PIM-1 up-regulation and cell proliferation
volume	383
year	2009
(literatureReference)	[Reaction:9703430] FLT3 fusions:GRB2 bind SOS1 [Homo sapiens] [BlackBoxEvent:9703432] p-STAT5 dissociates from FLT3 fusion proteinsp- [Homo sapiens] [Reaction:9703433] Ligand-independent dimerization of FLT3 fusion proteins [Homo sapiens] [Reaction:9703434] FLT3 fusions recruit PIK3CA through PIK3R1 [Homo sapiens] [BlackBoxEvent:9703435] FLT3 fusions activate STAT5 [Homo sapiens] [BlackBoxEvent:9703436] STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants [Homo sapiens] [Reaction:9703437] FLT3 fusion dimers autophosphorylate [Homo sapiens] [Reaction:9703439] FLT3 fusions recruit PIK3R1 through phosphorylated GAB2 [Homo sapiens] [Reaction:9703441] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 fusion mutants [Homo sapiens]
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