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Details on Person linafinib-resistant FLT3 mutants don't bind linifanib
| Class:Id | FailedReaction:9702997 |
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| _displayName | linafinib-resistant FLT3 mutants don't bind linifanib |
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| _doRelease | TRUE |
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| _timestamp | 2020-11-09 15:31:24 |
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| authored | [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 |
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| compartment | [Compartment:876] plasma membrane |
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| created | [InstanceEdit:9702999] Rothfels, Karen, 2020-10-03 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9702996] loss_of_function of linifanib-resistant FLT3 mutants [plasma membrane] |
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| input | [DefinedSet:9703000] linifanib-resistant FLT3 mutants [plasma membrane] [Homo sapiens]
[ChemicalDrug:9702979] linifanib [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9702972] The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway
[LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors |
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| modified | [InstanceEdit:9704328] Rothfels, Karen, 2020-10-07
[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9706836] Rothfels, Karen, 2020-11-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | linafinib-resistant FLT3 mutants don't bind linifanib |
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| normalReaction |
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| releaseDate | 2020-12-08 |
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| reviewed | [InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9703001] R-HSA-9702997.2 |
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| summation | [Summation:9704324] The following FLT3 mutants are resistant to linifanib-mediat... |
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| (hasEvent) | [Pathway:9702998] linifanib-resistant FLT3 mutants [Homo sapiens] |
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No pathways have been reviewed or authored by linafinib-resistant FLT3 mutants don't bind linifanib (9702997)
