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Details on Person sunitinib-resistant FLT3 mutants don't bind sunitinib
| Class:Id | FailedReaction:9702629 |
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| _displayName | sunitinib-resistant FLT3 mutants don't bind sunitinib |
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| _doRelease | TRUE |
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| _timestamp | 2020-11-06 20:56:42 |
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| authored | [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 |
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| compartment | [Compartment:876] plasma membrane |
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| created | [InstanceEdit:9702631] Rothfels, Karen, 2020-10-01 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9702630] loss_of_function of sunitinib-resistant FLT3 mutants [plasma membrane] |
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| input | [DefinedSet:9699528] sunitinib-resistant FLT3 mutants [plasma membrane] [Homo sapiens]
[ChemicalDrug:9669720] sunitinib [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib |
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| modified | [InstanceEdit:9702941] Rothfels, Karen, 2020-10-02
[InstanceEdit:9704328] Rothfels, Karen, 2020-10-07
[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | sunitinib-resistant FLT3 mutants don't bind sunitinib |
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| normalReaction |
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| releaseDate | 2020-12-08 |
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| reviewed | [InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9702634] R-HSA-9702629.2 |
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| summation | [Summation:9702928] The following FLT3 mutants are resistant to inhibition by su... |
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| (hasEvent) | [Pathway:9702632] sunitinib-resistant FLT3 mutants [Homo sapiens] |
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No pathways have been reviewed or authored by sunitinib-resistant FLT3 mutants don't bind sunitinib (9702629)
