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Details on Person gilteritinib-resistant FLT3 mutants don't bind gilteritinib

Class:IdFailedReaction:9702589
_displayNamegilteritinib-resistant FLT3 mutants don't bind gilteritinib
_doReleaseTRUE
_timestamp2020-11-09 15:31:18
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9702587] Rothfels, Karen, 2020-10-01
disease[Disease:1500689] cancer
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus[EntityFunctionalStatus:9702588] loss_of_function of gilteritinib-resistant FLT3 mutants [plasma membrane]
input[DefinedSet:9699533] gilteritinib-resistant FLT3 mutants [plasma membrane] [Homo sapiens]
[ChemicalDrug:9695700] gilteritinib [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9699321] Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia
[LiteratureReference:9699314] Gilteritinib is a clinically active FLT3 inhibitor with broad activity against FLT3 kinase domain mutations
modified[InstanceEdit:9702941] Rothfels, Karen, 2020-10-02
[InstanceEdit:9703074] Rothfels, Karen, 2020-10-05
[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9706836] Rothfels, Karen, 2020-11-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namegilteritinib-resistant FLT3 mutants don't bind gilteritinib
normalReaction
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9702592] R-HSA-9702589.2
summation[Summation:9702921] The following FLT3 mutants are resistant to inhibition by gi...
(hasEvent)[Pathway:9702590] gilteritinib-resistant FLT3 mutants [Homo sapiens]
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No pathways have been reviewed or authored by gilteritinib-resistant FLT3 mutants don't bind gilteritinib (9702589)
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