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Details on Person crenolanib-resistant FLT3 mutants don't bind crenolanib

Class:IdFailedReaction:9702583
_displayNamecrenolanib-resistant FLT3 mutants don't bind crenolanib
_doReleaseTRUE
_timestamp2020-11-06 20:55:44
authored[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9702582] Rothfels, Karen, 2020-10-01
disease[Disease:1500689] cancer
edited[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
entityFunctionalStatus[EntityFunctionalStatus:9702584] loss_of_function of crenolanib-resistant FLT3 mutants [plasma membrane]
input[DefinedSet:9699539] crenolanib-resistant FLT3 mutants [plasma membrane] [Homo sapiens]
[ChemicalDrug:9674072] crenolanib [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9683353] Targeting FLT3 mutations in AML: review of current knowledge and evidence
[LiteratureReference:9695671] Molecular targeting in acute myeloid leukemia
[LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
modified[InstanceEdit:9703073] Rothfels, Karen, 2020-10-05
[InstanceEdit:9704328] Rothfels, Karen, 2020-10-07
[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namecrenolanib-resistant FLT3 mutants don't bind crenolanib
normalReaction
releaseDate2020-12-08
reviewed[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9702585] R-HSA-9702583.2
summation[Summation:9703048] Crenolanib is a second-generation, type I tyrosine kinase in...
(hasEvent)[Pathway:9702581] crenolanib-resistant FLT3 mutants [Homo sapiens]
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No pathways have been reviewed or authored by crenolanib-resistant FLT3 mutants don't bind crenolanib (9702583)
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