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Details on Person semaxanib-resistant FLT3 mutants don't bind semaxanib
| Class:Id | FailedReaction:9702578 |
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| _displayName | semaxanib-resistant FLT3 mutants don't bind semaxanib
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| _doRelease | TRUE |
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| _timestamp | 2020-11-06 20:56:33 |
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| authored | [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 |
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| compartment | [Compartment:876] plasma membrane |
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| created | [InstanceEdit:9702576] Rothfels, Karen, 2020-10-01 |
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| disease | [Disease:1500689] cancer |
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| edited | [InstanceEdit:9706566] Rothfels, Karen, 2020-11-06 |
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| entityFunctionalStatus | [EntityFunctionalStatus:9702575] loss_of_function of semaxanib-resistant FLT3 mutants [plasma membrane] |
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| input | [DefinedSet:9699521] semaxanib-resistant FLT3 mutants [plasma membrane] [Homo sapiens]
[ChemicalDrug:9699412] semaxanib [cytosol] |
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| isChimeric | FALSE |
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| literatureReference | [LiteratureReference:9699301] FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L) |
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| modified | [InstanceEdit:9702941] Rothfels, Karen, 2020-10-02
[InstanceEdit:9704328] Rothfels, Karen, 2020-10-07
[InstanceEdit:9706570] Rothfels, Karen, 2020-11-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 |
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| name | semaxanib-resistant FLT3 mutants don't bind semaxanib
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| normalReaction |
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| releaseDate | 2020-12-08 |
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| reviewed | [InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06 |
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| reviewStatus | [ReviewStatus:9821382] five stars |
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| species | [Species:48887] Homo sapiens |
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| stableIdentifier | [StableIdentifier:9702579] R-HSA-9702578.2 |
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| summation | [Summation:9702927] The following FLT3 mutants are resistant to inhibition by se... |
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| (hasEvent) | [Pathway:9702577] semaxanib-resistant FLT3 mutants [Homo sapiens] |
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No pathways have been reviewed or authored by semaxanib-resistant FLT3 mutants don't bind semaxanib
(9702578)
