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Details on Person FLT mutants bind type II TKIs

Class:Id	Reaction:9702510
_displayName	FLT mutants bind type II TKIs
_doRelease	TRUE
_timestamp	2020-11-06 20:53:30
authored	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9702511] Rothfels, Karen, 2020-09-30
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9706566] Rothfels, Karen, 2020-11-06
input	[DefinedSet:9695783] type II FLT3-binding TKIs [cytosol] [DefinedSet:9702524] type II TKI sensitive FLT3 mutants [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases [LiteratureReference:9695653] FLT3 Inhibitors in Acute Myeloid Leukemia: Current Status and Future Directions [LiteratureReference:9703031] The importance of FLT3 mutational analysis in acute myeloid leukemia [LiteratureReference:9683353] Targeting FLT3 mutations in AML: review of current knowledge and evidence [LiteratureReference:9702954] FLT3 activating mutations display differential sensitivity to multiple tyrosine kinase inhibitors [LiteratureReference:9699359] Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns [LiteratureReference:9699282] FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27^Kip1 in acute myeloid leukemia [LiteratureReference:9699345] Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors [LiteratureReference:9699248] Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants [LiteratureReference:9699384] The secondary FLT3-ITD F691L mutation induces resistance to AC220 in FLT3-ITD+ AML but retains in vitro sensitivity to PKC412 and Sunitinib [LiteratureReference:9699279] FLT3 D835 mutations confer differential resistance to type II FLT3 inhibitors [LiteratureReference:9695676] Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518 [LiteratureReference:9699231] CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML) [LiteratureReference:9699254] Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib [LiteratureReference:9691860] FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248)
modified	[InstanceEdit:9702649] Rothfels, Karen, 2020-10-01 [InstanceEdit:9702944] Rothfels, Karen, 2020-10-02 [InstanceEdit:9703063] Rothfels, Karen, 2020-10-05 [InstanceEdit:9706570] Rothfels, Karen, 2020-11-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FLT mutants bind type II TKIs
normalReaction	[Reaction:9695831] FLT3 binds type II TKI [Homo sapiens]
output	[Complex:9702645] type II TKI-sensitive FLT3 mutants:type II TKIs [plasma membrane] [Homo sapiens]
releaseDate	2020-12-08
reviewed	[InstanceEdit:9706568] Kazi, Julhash U, 2020-11-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9702513] R-HSA-9702510.2
summation	[Summation:9702929] Type II tyrosine kinase inhibitors bind to a hydrophobic reg...
(hasEvent)	[Pathway:9702509] FLT3 mutants bind TKIs [Homo sapiens]
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