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Details on Person Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib
| Class:Id | LiteratureReference:9702293 |
| _displayName | Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib |
| _timestamp | 2020-09-29 20:56:35 |
| author | [Person:9702298] Ignatius Ou, Sai-Hong [Person:9702299] Azada, Michele [Person:9702295] Hsiang, David J [Person:9702297] Herman, June M [Person:9702294] Kain, Tatiana S [Person:9702300] Siwak-Tapp, Christina [Person:9702301] Casey, Cameron [Person:5662780] He, Jie [Person:5655437] Ali, Siraj M [Person:9634510] Klempner, Samuel J [Person:6800578] Miller, Vincent A |
| created | [InstanceEdit:9702296] Rothfels, Karen, 2020-09-29 |
| journal | J Thorac Oncol |
| pages | 549-53 |
| pubMedIdentifier | 24736079 |
| title | Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib |
| volume | 9 |
| year | 2014 |
| (literatureReference) | [DefinedSet:9700564] crizotinib resistant ALK mutants [plasma membrane] [Homo sapiens] [Reaction:9700662] Liganded-ALK dimer binds type I ALK-binding TKIs [Homo sapiens] [FailedReaction:9715357] crizotinib-resistant ALK mutants don't bind crizotinib [Homo sapiens] |
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No pathways have been reviewed or authored by Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib (9702293)