Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib

Class:IdLiteratureReference:9702293
_displayNameNext-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib
_timestamp2020-09-29 20:56:35
author[Person:9702298] Ignatius Ou, Sai-Hong
[Person:9702299] Azada, Michele
[Person:9702295] Hsiang, David J
[Person:9702297] Herman, June M
[Person:9702294] Kain, Tatiana S
[Person:9702300] Siwak-Tapp, Christina
[Person:9702301] Casey, Cameron
[Person:5662780] He, Jie
[Person:5655437] Ali, Siraj M
[Person:9634510] Klempner, Samuel J
[Person:6800578] Miller, Vincent A
created[InstanceEdit:9702296] Rothfels, Karen, 2020-09-29
journalJ Thorac Oncol
pages549-53
pubMedIdentifier24736079
titleNext-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib
volume9
year2014
(literatureReference)[DefinedSet:9700564] crizotinib resistant ALK mutants [plasma membrane] [Homo sapiens]
[Reaction:9700662] Liganded-ALK dimer binds type I ALK-binding TKIs [Homo sapiens]
[FailedReaction:9715357] crizotinib-resistant ALK mutants don't bind crizotinib [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib (9702293)