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Details on Person ALK-, STAT3- and MECP2-dependent STAT5A gene repression

Class:Id	BlackBoxEvent:9701903
_displayName	ALK-, STAT3- and MECP2-dependent STAT5A gene repression
_doRelease	TRUE
_timestamp	2021-05-04 17:33:33
authored	[InstanceEdit:9724129] Rothfels, Karen, 2021-03-22
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701902] Rothfels, Karen, 2020-09-28
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[EntityWithAccessionedSequence:9701805] STAT5A gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701412] Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma [LiteratureReference:9701758] STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
modified	[InstanceEdit:9718478] Rothfels, Karen, 2021-03-17 [InstanceEdit:9724130] Rothfels, Karen, 2021-03-22 [InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	ALK-, STAT3- and MECP2-dependent STAT5A gene repression
output	[EntityWithAccessionedSequence:9701901] STAT5A [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9701810] MECP2 binds the STAT5A gene [Homo sapiens] [BlackBoxEvent:9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9718477] Negative gene expression regulation by 'MECP2:STAT5A gene [nucleoplasm]'
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701904] R-HSA-9701903.2
summation	[Summation:9718439] STAT5A expression is repressed in NPM-ALK T-cell lymphomas i...
(hasEvent)	[Pathway:9725371] Nuclear events stimulated by ALK signaling in cancer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853220] Update Tracker - [BlackBoxEvent:9701903] ALK-, STAT3- and MECP2-dependent STAT5A gene repression - v87:[modifyText]
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No pathways have been reviewed or authored by ALK-, STAT3- and MECP2-dependent STAT5A gene repression (9701903)