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Details on Person p-7Y ALK L1198F [plasma membrane]

Class:Id	EntityWithAccessionedSequence:9701883
_displayName	p-7Y ALK L1198F [plasma membrane]
_timestamp	2020-09-28 00:24:58
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9701889] Rothfels, Karen, 2020-09-28
crossReference	[DatabaseIdentifier:9701285] COSMIC:COSM9311666 [DatabaseIdentifier:9701289] COSMIC:COSV66556391
disease	[Disease:1981182] lung squamous cell carcinoma [Disease:6802256] thyroid carcinoma
endCoordinate	1620
hasModifiedResidue	[ReplacedResidue:9701415] L-leucine 1198 replaced with L-phenylalanine [ModifiedResidue:9699796] O4'-phospho-L-tyrosine at 1096 [ModifiedResidue:9699868] O4'-phospho-L-tyrosine at 1278 [ModifiedResidue:9699844] O4'-phospho-L-tyrosine at 1282 [ModifiedResidue:9699911] O4'-phospho-L-tyrosine at 1283 [ModifiedResidue:9699876] O4'-phospho-L-tyrosine at 1359 [ModifiedResidue:9699886] O4'-phospho-L-tyrosine at 1507 [ModifiedResidue:9699803] O4'-phospho-L-tyrosine at 1604
literatureReference	[LiteratureReference:9700350] The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer [LiteratureReference:9701769] Anaplastic thyroid cancers harbor novel oncogenic mutations of the ALK gene
name	p-7Y ALK L1198F ALK tyrosine kinase receptor ALK_HUMAN
referenceEntity	[ReferenceGeneProduct:49894] UniProt:Q9UM73 ALK [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701893] R-HSA-9701883.1
startCoordinate	19
(hasComponent)	[Complex:9701888] p-7Y ALK L1198F dimer [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by p-7Y ALK L1198F [plasma membrane] (9701883)