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Details on Person ALK mutations conferring differential resistance to structurally diverse ALK inhibitors

Class:IdLiteratureReference:9701773
_displayNameALK mutations conferring differential resistance to structurally diverse ALK inhibitors
_timestamp2020-09-28 00:18:25
author[Person:1979957] Heuckmann, JM
[Person:6791142] Hölzel, Michael
[Person:1980009] Sos, ML
[Person:9701772] Heynck, Stefanie
[Person:1979919] Balke-Want, H
[Person:1979965] Koker, M
[Person:1979983] Peifer, M
[Person:1980028] Weiss, J
[Person:5683787] Lovly, Christine M
[Person:9701774] Grütter, Christian
[Person:1979991] Rauh, D
[Person:1181043] Pao, W
[Person:1980015] Thomas, RK
created[InstanceEdit:9701775] Rothfels, Karen, 2020-09-28
journalClin. Cancer Res.
pages7394-401
pubMedIdentifier21948233
titleALK mutations conferring differential resistance to structurally diverse ALK inhibitors
volume17
year2011
(literatureReference)[FailedReaction:9700114] NVP-TAE684-resistant ALK mutants don't bind NVP-TAE684 [Homo sapiens]
[Reaction:9700131] ALK mutants bind type I TKIs [Homo sapiens]
[FailedReaction:9715357] crizotinib-resistant ALK mutants don't bind crizotinib [Homo sapiens]
[Pathway:9717301] NVP-TAE684-resistant ALK mutants [Homo sapiens]
[DefinedSet:9700081] NVP-TAE684-sensitive ALK mutants [cytosol] [Homo sapiens]
[DefinedSet:9700564] crizotinib resistant ALK mutants [plasma membrane] [Homo sapiens]
[DefinedSet:9700568] NVP-TAE684-resistant ALK mutants [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9701826] ALK L1198P [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9701835] ALK G1269S [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:9716099] ALK G1123D [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by ALK mutations conferring differential resistance to structurally diverse ALK inhibitors (9701773)