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Details on Person Nova1 contains three HNRNPK homology (KH) domains which bind...
| Class:Id | Summation:9701664 |
|---|---|
| _displayName | Nova1 contains three HNRNPK homology (KH) domains which bind... |
| _timestamp | 2021-04-12 15:07:34 |
| created | [InstanceEdit:9701597] May, Bruce, 2020-09-27 |
| modified | [InstanceEdit:9701721] May, Bruce, 2020-09-27 [InstanceEdit:9726833] May, Bruce, 2021-04-12 |
| text | Nova1 contains three HNRNPK homology (KH) domains which bind RNA at consensus motifs containing YCAY (Y is C or U) (Ule et al. 2006). After binding RNA, Nova1 regulates subsequent splicing of pre-mRNAs, possibly by influencing access of snRNPs to the pre-mRNA. Usually Nova1 bound to exonic sequences or upstream intronic sequences promotes exon exclusion (exon skipping) while Nova1 bound to downstream intronic sequences promotes exon inclusion (Ule et al. 2006). Nova1 was originally isolated from neurons and has subsequently been found in other cell types including pancreatic beta cells, fibroblasts, endothelial cells, and epithelial cells (Mallinjoud et al. 2014). Notable RNA targets of Nova1 include Dcc (Leggere et al. 2016), Gabrg2 (Zhang et al. 2010), Glra2 (Buckanovich and Darnell 1997, Jensen et al. 2000), and Nova1 (Buckanovich and Darnell 1997, Dredge et al. 2005). |
| (summation) | [Reaction:9701643] Nova1 binds introns of pre-mRNA [Mus musculus] |
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No pathways have been reviewed or authored by Nova1 contains three HNRNPK homology (KH) domains which bind... (9701664)
