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Details on Person HDACs deacetylate p-STAT3 dimers

Class:Id	Reaction:9701565
_displayName	HDACs deacetylate p-STAT3 dimers
_doRelease	TRUE
_timestamp	2021-05-04 17:34:54
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
catalystActivity	[CatalystActivity:9701521] protein lysine deacetylase activity of Histone deacetylase [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701566] Rothfels, Karen, 2020-09-26
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[Complex:9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens] [SimpleEntity:113518] H2O [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701374] Stat3 dimerization regulated by reversible acetylation of a single lysine residue
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HDACs deacetylate p-STAT3 dimers
output	[Complex:9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens] [SimpleEntity:427486] CH3COO- [nucleoplasm]
precedingEvent	[Reaction:9701531] p-Y705,S727 STAT3 is acetylated [Homo sapiens] [BlackBoxEvent:9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701567] R-HSA-9701565.2
summation	[Summation:9701505] HDAC1, 2, and 3 deacetylate lysine 685 of STAT3. Deacetylati...
(hasEvent)	[Pathway:9701898] STAT3 nuclear events downstream of ALK signaling [Homo sapiens]
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No pathways have been reviewed or authored by HDACs deacetylate p-STAT3 dimers (9701565)