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Details on Person CD274 gene expression downstream of ALK signaling

Class:Id	BlackBoxEvent:9701562
_displayName	CD274 gene expression downstream of ALK signaling
_doRelease	TRUE
_timestamp	2021-05-04 17:34:49
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701563] Rothfels, Karen, 2020-09-26
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[EntityWithAccessionedSequence:9701419] CD274 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701294] Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1) [LiteratureReference:9701340] PD-L1
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CD274 gene expression downstream of ALK signaling
output	[EntityWithAccessionedSequence:3211776] CD274 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9701537] p-Y705, S727 STAT3 dimer binds CD274 gene [Homo sapiens] [BlackBoxEvent:9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9701542] Positive gene expression regulation by 'p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm]'
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701564] R-HSA-9701562.2
summation	[Summation:9701495] ALK signaling promotes expression of the CD274 gene by stimu...
(hasEvent)	[Pathway:9701898] STAT3 nuclear events downstream of ALK signaling [Homo sapiens]
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No pathways have been reviewed or authored by CD274 gene expression downstream of ALK signaling (9701562)