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Details on Person IL2RG gene expression downstream of ALK signaling

Class:Id	BlackBoxEvent:9701556
_displayName	IL2RG gene expression downstream of ALK signaling
_doRelease	TRUE
_timestamp	2023-11-09 18:37:17
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701555] Rothfels, Karen, 2020-09-26
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[EntityWithAccessionedSequence:9701417] IL2RG gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729687] Rothfels, Karen, 2021-05-03 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9850956] Rothfels, Karen, 2023-10-12 [InstanceEdit:9853043] Rothfels, Karen, 2023-11-09
name	IL2RG gene expression downstream of ALK signaling
output	[EntityWithAccessionedSequence:449139] IL2RG [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter [Homo sapiens] [Reaction:9701531] p-Y705,S727 STAT3 is acetylated [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeGeneExpressionRegulation:9701545] Negative gene expression regulation by 'SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]' [NegativeGeneExpressionRegulation:9850955] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]'
regulationReference	[RegulationReference:9850959] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK [RegulationReference:9850957] Negative gene expression regulation by 'SIN3A:ACK685-p-Y705,S727 STAT3 dimer:IL2RG gene [nucleoplasm]' The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701559] R-HSA-9701556.3
structureModified	[InstanceEdit:9850956] Rothfels, Karen, 2023-10-12
summation	[Summation:9701554] IL2RG gene expression is repressed by a complex of SIN3A and...
(hasEvent)	[Pathway:9701898] STAT3 nuclear events downstream of ALK signaling [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853282] Update Tracker - [BlackBoxEvent:9701556] IL2RG gene expression downstream of ALK signaling - v87:[addRegulator]
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No pathways have been reviewed or authored by IL2RG gene expression downstream of ALK signaling (9701556)