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Details on Person PRDM1 gene expression downstream of ALK signaling

Class:Id	BlackBoxEvent:9701548
_displayName	PRDM1 gene expression downstream of ALK signaling
_doRelease	TRUE
_timestamp	2021-05-04 17:35:53
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701550] Rothfels, Karen, 2020-09-26
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[EntityWithAccessionedSequence:6804192] PRDM1 Gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3 [LiteratureReference:9701411] PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma [LiteratureReference:9702103] PRDM1/BLIMP1: a tumor suppressor gene in B and T cell lymphomas
modified	[InstanceEdit:9702121] Rothfels, Karen, 2020-09-29 [InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRDM1 gene expression downstream of ALK signaling
output	[EntityWithAccessionedSequence:6804199] PRDM1 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9701549] AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter [Homo sapiens] [Reaction:9701531] p-Y705,S727 STAT3 is acetylated [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9701547] Negative gene expression regulation by 'SIN3A:AcK685,p-Y705,p-S727 STAT3 dimer:PRDM1 gene [nucleoplasm]'
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701551] R-HSA-9701548.2
summation	[Summation:9701511] PRDM1 gene expression is repressed by a complex of SIN3A and...
(hasEvent)	[Pathway:9701898] STAT3 nuclear events downstream of ALK signaling [Homo sapiens]
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No pathways have been reviewed or authored by PRDM1 gene expression downstream of ALK signaling (9701548)