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Details on Person p-Y705, S727 STAT3 dimer binds CD274 gene

Class:Id	Reaction:9701537
_displayName	p-Y705, S727 STAT3 dimer binds CD274 gene
_doRelease	TRUE
_timestamp	2021-05-04 17:36:51
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9701538] Rothfels, Karen, 2020-09-26
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[Complex:9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9701419] CD274 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701340] PD-L1 [LiteratureReference:9701294] Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y705, S727 STAT3 dimer binds CD274 gene
output	[Complex:9701462] p-Y705, S727 STAT3 dimer:CD274 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus [Homo sapiens] [Reaction:9701525] p-Y705,S727-STAT3 dimerizes [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701539] R-HSA-9701537.2
summation	[Summation:9701494] ALK induces expression of the plasma membrane immunosuppress...
(hasEvent)	[Pathway:9701898] STAT3 nuclear events downstream of ALK signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9701562] CD274 gene expression downstream of ALK signaling [Homo sapiens]
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No pathways have been reviewed or authored by p-Y705, S727 STAT3 dimer binds CD274 gene (9701537)