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Details on Person p-Y705,S727 STAT3 is acetylated

Class:Id	Reaction:9701531
_displayName	p-Y705,S727 STAT3 is acetylated
_doRelease	TRUE
_timestamp	2021-05-04 17:36:59
authored	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
catalystActivity	[CatalystActivity:9701519] protein-lysine-acetyltransferase activity of EP300 [nucleoplasm]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9701528] Rothfels, Karen, 2020-09-26
edited	[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input	[Complex:9701457] p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens] [SimpleEntity:113560] Ac-CoA [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701374] Stat3 dimerization regulated by reversible acetylation of a single lysine residue
modified	[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-Y705,S727 STAT3 is acetylated
output	[Complex:9701465] AcK685- p-Y705,S727-STAT3 dimer [nucleoplasm] [Homo sapiens] [SimpleEntity:2485002] CoA-SH [nucleoplasm]
precedingEvent	[BlackBoxEvent:9701529] p-Y705, p-S727 STAT3 dimer translocates to the nucleus [Homo sapiens] [Reaction:9701525] p-Y705,S727-STAT3 dimerizes [Homo sapiens]
releaseDate	2021-06-09
reviewed	[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9701532] R-HSA-9701531.2
summation	[Summation:9701530] Phosphorylated STAT3 is acetylated by p300 at lysine 685, st...
(hasEvent)	[Pathway:9701898] STAT3 nuclear events downstream of ALK signaling [Homo sapiens]
(precedingEvent)	[Reaction:9701549] AcK685-p-Y705,S727 STAT3 and SIN3A bind the PDRM1 promoter [Homo sapiens] [Reaction:9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter [Homo sapiens] [Reaction:9701565] HDACs deacetylate p-STAT3 dimers [Homo sapiens] [Reaction:9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene [Homo sapiens] [Reaction:9851062] AcK685 pY705,S727 STAT3 binds the MIR21 gene [Homo sapiens] [Reaction:9851064] AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9853224] Update Tracker - [Reaction:9701531] p-Y705,S727 STAT3 is acetylated - v87:[modifyText]
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No pathways have been reviewed or authored by p-Y705,S727 STAT3 is acetylated (9701531)