Query author contributions in Reactome Reactome depends on collaboration between our curation team and outside experts to
assemble and peer-review its pathway modules. The integration of ORCID within Reactome
enables us to meet a key challenge with authoring, curating and reviewing biological
information by incentivizing and crediting the external experts that contribute their
expertise and time to the Reactome curation process. More information is available at
ORCID and Reactome .
If you have an ORCID ID that is not listed on this page, please
forward this information to us and we will update your Reactome pathway records.
Details on Person STAT3 is phosphorylated downstream of active ALK
Class:Id BlackBoxEvent:9701524 _displayName STAT3 is phosphorylated downstream of active ALK _doRelease TRUE _timestamp 2023-11-09 18:37:22 authored [InstanceEdit:9725664] Rothfels, Karen, 2021-03-30 compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol created [InstanceEdit:9701523] Rothfels, Karen, 2020-09-26 edited [InstanceEdit:9725664] Rothfels, Karen, 2021-03-30 input [EntityWithAccessionedSequence:539044] STAT3 [cytosol] [Homo sapiens] [CandidateSet:9850879] Active ALK dimer [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death [LiteratureReference:9701412] Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma [LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma [LiteratureReference:9701343] NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors [LiteratureReference:9701357] Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target [LiteratureReference:9843053] Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells [LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells [LiteratureReference:9667881] The anaplastic lymphoma kinase in the pathogenesis of cancer [LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease [LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma [LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma [LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma [LiteratureReference:9701292] Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3 [LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells [LiteratureReference:9701314] The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3 modified [InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9850956] Rothfels, Karen, 2023-10-12 [InstanceEdit:9853043] Rothfels, Karen, 2023-11-09 name STAT3 is phosphorylated downstream of active ALK output [EntityWithAccessionedSequence:539048] p-Y705,S727-STAT3 [cytosol] [Homo sapiens] precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars releaseDate 2021-06-09 reviewed [InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9701527] R-HSA-9701524.3 structureModified [InstanceEdit:9850956] Rothfels, Karen, 2023-10-12 summation [Summation:9701516] STAT3 is phosphorylated at tyrosine 705 downstream of active... (hasEvent) [Pathway:201556] Signaling by ALK [Homo sapiens] (normalReaction) [Reaction:9712079] ALK mutants bind STAT3 [Homo sapiens] (precedingEvent) [Reaction:9701525] p-Y705,S727-STAT3 dimerizes [Homo sapiens] (updatedInstance) [_UpdateTracker:9853301] Update Tracker - [BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK - v87:[addLiteratureReference, add_removeInput, modifyText]
[Change default viewing format]
List...
Protein identifiers
ChEBI identifiers
KEGG COMPOUND identifiers
No pathways have been reviewed or authored by STAT3 is phosphorylated downstream of active ALK (9701524)
