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Details on Person Active ALK phosphorylates JAK3

Class:IdReaction:9701488
_displayNameActive ALK phosphorylates JAK3
_doReleaseTRUE
_timestamp2021-05-04 17:34:24
authored[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
catalystActivity[CatalystActivity:9701490] protein tyrosine kinase activity of Active ALK:JAK3 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9701491] Rothfels, Karen, 2020-09-26
edited[InstanceEdit:9725664] Rothfels, Karen, 2021-03-30
input[Complex:9701478] Active ALK:JAK3 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death
[LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma
[LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma
[LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
[LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma
[LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells
[LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease
modified[InstanceEdit:9729590] Rothfels, Karen, 2021-04-30
[InstanceEdit:9729893] Rothfels, Karen, 2021-05-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActive ALK phosphorylates JAK3
output[SimpleEntity:29370] ADP [cytosol]
[Complex:9701475] Active ALK:p-Y980 JAK3 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2021-06-09
reviewed[InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9701492] R-HSA-9701488.2
summation[Summation:9701489] JAK3 is phosphorylated downstream of active ALK signaling (Z...
(hasEvent)[Pathway:201556] Signaling by ALK [Homo sapiens]
(precedingEvent)[Reaction:9701507] PTPN6 dephosphorylates JAK3 [Homo sapiens]
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No pathways have been reviewed or authored by Active ALK phosphorylates JAK3 (9701488)
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