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Details on Person Active ALK binds JAK3
Class:Id Reaction:9701485 _displayName Active ALK binds JAK3 _doRelease TRUE _timestamp 2023-11-09 18:36:58 authored [InstanceEdit:9725664] Rothfels, Karen, 2021-03-30 compartment [Compartment:70101] cytosol [Compartment:876] plasma membrane created [InstanceEdit:9701486] Rothfels, Karen, 2020-09-26 edited [InstanceEdit:9725664] Rothfels, Karen, 2021-03-30 input [EntityWithAccessionedSequence:451893] JAK3 [cytosol] [Homo sapiens] [CandidateSet:9850879] Active ALK dimer [plasma membrane] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:9701321] Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death [LiteratureReference:9701338] Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma [LiteratureReference:9701292] Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3 [LiteratureReference:9701408] Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma [LiteratureReference:9701348] Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma [LiteratureReference:9701413] Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma [LiteratureReference:9701315] JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells [LiteratureReference:9843020] Fusion tyrosine kinase mediated signalling pathways in the transformation of haematopoietic cells [LiteratureReference:9699641] Anaplastic lymphoma kinase: signalling in development and disease modified [InstanceEdit:9729590] Rothfels, Karen, 2021-04-30 [InstanceEdit:9729893] Rothfels, Karen, 2021-05-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9850956] Rothfels, Karen, 2023-10-12 [InstanceEdit:9853041] Rothfels, Karen, 2023-11-09 name Active ALK binds JAK3 output [Complex:9701478] Active ALK:JAK3 [plasma membrane] [Homo sapiens] precedingEvent
previousReviewStatus [ReviewStatus:9821384] two stars releaseDate 2021-06-09 reviewed [InstanceEdit:9729891] Inghirami, Giorgio, 2021-05-04 [InstanceEdit:9852935] Turner, Suzanne, 2023-11-08 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9701487] R-HSA-9701485.3 structureModified [InstanceEdit:9850956] Rothfels, Karen, 2023-10-12 summation [Summation:9701484] Based on studies with NPM-ALK fusion proteins, ALK appears t... (hasEvent) [Pathway:201556] Signaling by ALK [Homo sapiens] (precedingEvent) [Reaction:9701488] Active ALK phosphorylates JAK3 [Homo sapiens] (updatedInstance) [_UpdateTracker:9853237] Update Tracker - [Reaction:9701485] Active ALK binds JAK3 - v87:[addLiteratureReference, add_removeInput, modifyText]
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