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Details on Person Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma

Class:Id	LiteratureReference:9701413
_displayName	Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
_timestamp	2020-09-26 21:53:07
author	[Person:9701388] Han, Yajun [Person:9699720] Amin, Hesham M [Person:9701358] Franko, Bevin [Person:9701305] Frantz, Christine [Person:9701366] Shi, Xinzhe [Person:5665605] Lai, Raymond
created	[InstanceEdit:9701293] Rothfels, Karen, 2020-09-26
journal	Blood
pages	2796-803
pubMedIdentifier	16825495
title	Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma
volume	108
year	2006
(literatureReference)	[Reaction:9701485] Active ALK binds JAK3 [Homo sapiens] [Reaction:9701488] Active ALK phosphorylates JAK3 [Homo sapiens] [Reaction:9701507] PTPN6 dephosphorylates JAK3 [Homo sapiens] [BlackBoxEvent:9701524] STAT3 is phosphorylated downstream of active ALK [Homo sapiens] [Reaction:9712079] ALK mutants bind STAT3 [Homo sapiens] [BlackBoxEvent:9850958] pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants [Homo sapiens]
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No pathways have been reviewed or authored by Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma (9701413)