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Details on Person IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK

Class:Id	LiteratureReference:9701299
_displayName	IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
_timestamp	2020-09-26 21:52:37
author	[Person:8858043] Zhang, Qian [Person:9701392] Wang, Hong Yi [Person:9701307] Liu, Xiaobin [Person:9701303] Bhutani, Gauri [Person:9701405] Kantekure, Kanchan [Person:9701291] Wasik, Mariusz
created	[InstanceEdit:9701293] Rothfels, Karen, 2020-09-26
journal	Proc. Natl. Acad. Sci. U.S.A.
pages	11977-82
pubMedIdentifier	21715655
title	IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
volume	108
year	2011
(literatureReference)	[Reaction:9701557] AcK685-p-Y705,S727 STAT3 and SIN3A bind the IL2RG promoter [Homo sapiens] [Reaction:9851058] AcK685 p-Y705, S727 STAT3 dimer and DNMT1 bind IL2RG gene [Homo sapiens] [Reaction:9851062] AcK685 pY705,S727 STAT3 binds the MIR21 gene [Homo sapiens] [Reaction:9851064] AcK685-pY705,S727 STAT3 dimer binds DNMT1 promoter [Homo sapiens] [BlackBoxEvent:9851137] STAT3-dependent DNMT1 gene expression [Homo sapiens] [BlackBoxEvent:9851139] STAT3-dependent MIR-21 gene expression [Homo sapiens] [BlackBoxEvent:9851145] Translation of DNMT1 mRNA is repressed by miR-21 [Homo sapiens] [Reaction:9851147] miR-21 RISC binds DNMT1 mRNA [Homo sapiens] [RegulationReference:9850959] Negative gene expression regulation by 'DNMT1:AcK685-p-Y705, S727 STAT3 dimer:IL2RG gene [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK [RegulationReference:9851012] Negative gene expression regulation by 'MIR21 gene:AcK685-pY705,p-S727 STAT3 dimer [nucleoplasm]' IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK List all 11 refering instances
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