Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person BRCA1:BARD1 heterodimer autoubiquitinates

Class:IdReaction:9701000
_displayNameBRCA1:BARD1 heterodimer autoubiquitinates
_doReleaseTRUE
_timestamp2026-04-06 20:30:21
authored[InstanceEdit:9702562] Orlic-Milacic, Marija, 2020-09-30
catalystActivity[CatalystActivity:9701027] ubiquitin-protein transferase activity of BRCA1:BARD1 [nucleoplasm]
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9701005] Orlic-Milacic, Marija, 2020-09-23
edited[InstanceEdit:9706872] Orlic-Milacic, Marija, 2020-11-09
[InstanceEdit:9986873] Orlic-Milacic, Marija, 2026-04-06
input[Complex:5659802] BRCA1:BARD1 [nucleoplasm] [Homo sapiens]
[DefinedSet:6782648] K6-Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:6782648] K6-Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:6782648] K6-Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:6782648] K6-Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:6782648] K6-Ub [nucleoplasm] [Homo sapiens]
[DefinedSet:6782648] K6-Ub [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9701008] Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase
[LiteratureReference:9700997] The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
[LiteratureReference:9701001] Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
[LiteratureReference:9986874] BRCA1/BARD1 intrinsically disordered regions facilitate chromatin recruitment and ubiquitylation
[LiteratureReference:9986890] Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair
modified[InstanceEdit:9701021] Orlic-Milacic, Marija, 2020-09-23
[InstanceEdit:9701032] Orlic-Milacic, Marija, 2020-09-23
[InstanceEdit:9701034] Orlic-Milacic, Marija, 2020-09-23
[InstanceEdit:9701940] Orlic-Milacic, Marija, 2020-09-28
[InstanceEdit:9707068] Orlic-Milacic, Marija, 2020-11-10
[InstanceEdit:9707093] Orlic-Milacic, Marija, 2020-11-10
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9986904] Orlic-Milacic, Marija, 2026-04-06
nameBRCA1:BARD1 heterodimer autoubiquitinates
output[Complex:9701028] K6PolyUb-BRCA1:K6PolyUb-BARD1 [nucleoplasm] [Homo sapiens]
precedingEvent
regulatedBy[NegativeRegulation:8868791] Negative regulation by 'BAP1:BARD1 [nucleoplasm]'
releaseDate2020-12-08
reviewed[InstanceEdit:9706944] Baer, Richard J, 2020-11-04
[InstanceEdit:9986900] Zhao, Weixing, 2026-02-10
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9701011] R-HSA-9701000.2
summation[Summation:9701020] In vivo, most BRCA1 and BARD1 polypeptides exist in the form...
(hasEvent)[Pathway:5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks [Homo sapiens]
(precedingEvent)[Reaction:5683385] Formation of BRCA1-A complex at DNA DSBs [Homo sapiens]
[Reaction:9707051] UBXN1 binds BRCA1:BARD1 heterodimer [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by BRCA1:BARD1 heterodimer autoubiquitinates (9701000)
Follow Reactome