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Details on Person NOVA1 binds intron of pre-mRNA

Class:Id	Reaction:9700862
_displayName	NOVA1 binds intron of pre-mRNA
_timestamp	2024-04-20 21:24:11
authored	[InstanceEdit:9700855] May, Bruce, 2020-09-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9700859] May, Bruce, 2020-09-19
edited	[InstanceEdit:9700855] May, Bruce, 2020-09-14
inferredFrom	[Reaction:9701643] Nova1 binds introns of pre-mRNA [Mus musculus]
input	[EntityWithAccessionedSequence:9699193] NOVA1 [nucleoplasm] [Homo sapiens] [Complex:9908324] pre-mRNA with intron targeted by NOVA1:CBC:RNA pol II [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9701668] The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain [LiteratureReference:9701582] NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells [LiteratureReference:9701609] NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer [LiteratureReference:9701673] RBM4-Nova1-SRSF6 splicing cascade modulates the development of brown adipocytes [LiteratureReference:9701686] The impact of the RBM4-initiated splicing cascade on modulating the carcinogenic signature of colorectal cancer cells [LiteratureReference:9701669] Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1 [LiteratureReference:9701714] Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome
modified	[InstanceEdit:9701711] May, Bruce, 2020-09-27 [InstanceEdit:9701721] May, Bruce, 2020-09-27 [InstanceEdit:9908365] May, Bruce, 2024-04-20
name	NOVA1 binds intron of pre-mRNA
output	[Complex:9908296] NOVA1 bound to intron of pre-mRNA:CBC:RNA pol II [nucleoplasm] [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9700871] R-HSA-9700862.1
structureModified	[InstanceEdit:9908365] May, Bruce, 2024-04-20
summation	[Summation:9701603] Neuro-oncological ventral antigen 1 (NOVA1) and NOVA2 are al...
(hasEvent)	[Pathway:9939002] Alternative splicing of pre-RNA with Alternative Splicing Factor bound to intron [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9700856] Splicing of pre-mRNA bound by NOVA1 [Homo sapiens] [BlackBoxEvent:9908308] Formation of the Spliceosomal E complex containing Alternative Splicing Factor [Homo sapiens]
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No pathways have been reviewed or authored by NOVA1 binds intron of pre-mRNA (9700862)